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p62 Ick ligand Mouse anti-Human, Unlabeled, Clone: 3, BD

Mouse Monoclonal Antibody

$232.00 - $458.00

Specifications

Antigen p62 Ick ligand
Isotype IgG1, κ
Immunogen Human p62 lck ligand aa. 257-437
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610833
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BD Biosciences
610833
150μg
Each for $458.00
Add to cart
 
BDB610832
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BD Biosciences
610832
50μg
Each for $232.00
Add to cart
 
Description

Description

p62 lck ligand (zeta-interacting protein (ZIP)) is a cytoplasmic protein that binds to the SH2 domain of lck (a T cell src tyrosine kinase) in the absence of a phosphotyrosine in either protein. The ubiquitously expressed p62 lck ligand contains a cysteine rich region that is similar to a zinc finger domain, a G protein binding region, a PEST sequence, and several phosphorylation sites. Deletion of the p62 lck ligand N-terminal domain has been reported to abrogate its binding to lck. However, mutation of the tyrosine did not have an effect. In addition, p62 lck ligand binds to the pseudosubstrate region of the PKCζ catalytic domain. In turn, PKCζ phosphorylates p62. p62 lck ligand binds to the dimerization region of PKCζ, thereby inhibiting PKCζ-PKCζ interaction. This suggests that p62 lck ligand may compete with PKCζ. However, it requires PKCζ for proper subcellular localization. These data suggest that p62 lck ligand may be part of the protein bridge that links PKCζ to the tyrosine kinases involved in signaling pathways.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

p62 Ick ligand
Human p62 lck ligand aa. 257-437
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Zeta Interacting Protein (ZIP); SQSMT1
IgG1, κ
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
3
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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