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MilliporeSigma™ anti-PAI-1 Clone: 2,

Catalog No. IM29L100UG Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
IM29L100UG 100 μg Unconjugated
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Catalog No. IM29L100UG Supplier MilliporeSigma™ Supplier No. IM29L100UG
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Description

Mouse Monoclonal Antibody

Specifically detects PAI-1 Clone: 2 in Human samples, and it is validated for Immunocytochemistry, Immunoprecipitation, Neutralization

Plasminogen activator inhibitor 1 (PAI-1) is a secreted glycoprotein of approximately 50kDa, which functions as the primary regulator of uPA and tPA activity. PAI-1 and the related inhibitor, PAI-2, are members of the serine proteinase inhibitor (serpin) gene superfamily. PAI-1 is produced by a variety of cell types and is present in normal human plasma. It exists as two conformationally distinct forms, latent and active. The active form binds to uPA in a 1:1 complex resulting in the inhibition of proteolytic activity. Active PAI-1 rapidly converts to the latent form but can be stabilized in the active conformation by binding to the cell adhesion glycoprotein, vitronectin. Latent PAI-1 can be activated in vitro by exposure to denaturants such as SDS or guanidine. PAI-1 levels are increased in a number of disease states including coronary artery disease, venous thrombosis, obesity and various types of cancer. Recent studies indicate that elevated PAI-1 may be a useful prognostic marker for several types of cancers, particularly breast and lung.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PAI-1
Applications Immunocytochemistry, Immunoprecipitation, Neutralization
Classification Monoclonal
Clone 2
Conjugate Unconjugated
Formulation Lyophilized from a volatile buffer, 100μg BSA.
Host Species Mouse
Immunogen partially purified PAI-1 from conditioned medium of dexamethasone-treated HT1080 human cells
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes both active and latent forms of the ∽50kDa PAI-1 protein in conditioned media from dexamethasone-treated HT-1080 cells. Sold under license of U.S. Patent 5,422,245.
Target Species Human
Content And Storage 2°C to 8°C
Form Purified
Isotype IgG1
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