Pan Carcinoma, 40kDa Mouse anti-Human, Unlabeled, Clone: KS1/4, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 554276

Catalog No. BDB554276

Description

KS1/4 antigen (Ag), defined by the KS1/4 antibody (KS1/4), is expressed in many epithelial-derived carcinomas and normal epithelial cell surfaces. The cDNA encoding KS1/4 has been isolated and contains an open reading frame of 314 amino acids including a putative signal sequence. KS1/4 Ag migrates as three glycosylated polypeptides with molecular masses of 35, 40 and 42kDa. The 40 and 42kDa species are similar proteins and appear to differ only by their degree of N-linked glycosylation. The 35kDa species results from proteolytic cleavages of the larger molecular weight proteins. KS1/4 was first described as a monoclonal antibody which recognized a lung adenocarcinoma associated antigen. In oncolytic drug targeting studies, KS1/4 suppressed the growth of human lung tumor xenografts in athymic nude mice. Subsequent studies showed that KS1/4 reacts with a variety of tumor tissues including colon, breast, ovarian, and pancreas. It also recognizes normal epithelium including colon, stomach, small intestine, liver, kidney, lung, pancreas, skin and ovary. These results suggest that KS1/4 Ag represents an epithelial cell/epithelial-derived carcinoma marker. KS1/4 recognizes a 40 - 42kDa antigen expressed on the cell surfaces of a
variety of epithelial tumors and normal epithelial cell types. KS1/4 also recognizes a 35kDa proteolytic fragment. UCLA-P3 cells derived from a human adenocarcinoma of the lung were used as immunogen.

Host Species: Mouse
Clone: KS1/4
Isotype: IgG2a
Species Reactivity: Human
Immunogen: UCLA-P3 cells

Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation

Specifications

• Antigen: Pan Carcinoma, 40kDa
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: UCLA-P3 cells
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human
• Isotype: IgG2a

• Applications: Flow Cytometry
• Clone: KS1/4
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.