MilliporeSigma™ anti-Pan-Ras Clone: F132-62,

Catalog No.	Quantity	Conjugate
OP21100UG	100 μg	Unconjugated

Catalog No. OP21100UG Supplier MilliporeSigma™ Supplier No. OP21100UG

Description

Mouse Monoclonal Antibody

Specifically detects Pan-Ras Clone: F132-62 in Human, Mouse, Rat samples, and it is validated for Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation

The human ras gene family consists of three identified members, H-, K- and N-ras, encoding proteins of 188-189 amino acids and 21,000 (p21) molecular weight. Human H- and K-ras are the homologues of v-H- and v-K-ras sequences originally isolated from Harvey and Kirsten strains of rat sarcoma viruses. Normal human cellular ras genes can be activated to oncogenes by mutations occurring in codons 12, 13 and 61; such mutated, activated and transforming ras genes have been identified and isolated from human tumors and cultured tumor cells. Although the expression patterns of ras proto-oncogene proteins in normal human tissues are known, similar information for activated ras oncogene encoded p21s and their relevance to human disease diagnosis and prognosis remains to be determined.

Specifications

• Antigen: Pan-Ras
• Applications: Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
• Classification: Monoclonal
• Clone: F132-62
• Conjugate: Unconjugated
• Formulation: In 0.05M sodium phosphate buffer, 0.2% gelatin.
• Host Species: Mouse
• Immunogen: recombinant p21 Ras
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽21kDa H-, K-, and N-Ras proteins including both c- and v- Ras in SW480 and Y1 cells and normal skin tissue.
• Target Species: Human, Mouse, Rat
• Content And Storage: 2°C to 8°C
• Form: Purified
• Isotype: IgG2b

For Research Use Only