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alpha Synuclein Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA118253

Catalog No. 01-670-506

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Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.

PA1-18253 detects alpha, beta, and gamma Synuclein from human and rat samples.PA1-18253 has been successfully used in immunohistochemistry and Western blot procedures.The PA1-18253 immunogen is a synthetic peptide corresponding to residues A K E G V V A A A E K T K Q G V of a consensus part of human alpha-, beta-, and gamma synuclein proteins, conjugated to diphteria toxoid.Reconstitute with 100 ul of distilled water.


alpha Synuclein
whole serum with no preservative
P37840, P37377
MGC110988, NACP, PARK1, PARK4, PD1
Human, Rat
Immunohistochemistry, Western Blot
Synthetic peptide corresponding to residues A K E G V V A A A E K T K Q G V of a consensus part of human alpha-, beta-, and gamma synuclein proteins.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
29219, 6622
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