MilliporeSigma™ anti-Pannexin-1/PANX1, Polyclonal

Catalog No.	Quantity	Conjugate
ABN242MI	100 μg	Unconjugated

Catalog No. ABN242MI Supplier MilliporeSigma™ Supplier No. ABN242

Description

Rabbit Polyclonal Antibody

Specifically detects Pannexin-1/PANX1 Clone: in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry, Western Blotting

Pannexin-1 (UniProt Q96RD7; also known as Innexin) is encoded by the PANX1 (also known as MRS1, PX1) gene (ORF UNQ2529/PRO6028; Gene ID 24145) in human. Pannexin 1 is a high-conductance, voltage-gated channel protein widely expressed in many organs and tissues, including the sensory systems (eye, inner ear, taste buds, and the olfactory epithelium) and both neuronal and non-neuronal cell types. Three pannexin family genes (PANX1-3) have been identified in human and mouse genomes. Pannexin proteins share structural and functional similarities and play important roles in many physiological and pathological processes, such as ATP release, Ca2+ homeostasis, synaptic neurotransmitters release, apoptosis, and immunological response. Pannexin-1 deficiency causes caspase-3 activation and apoptosis induction of hair cells in cochlear spiral limbus (SLM), resulting in hearing loss among Panx1-/- mice. Panx1 is also expressed in the retina, lens and cornea of the eye, where it plays an important role in mediating the crosstalk between immune and neuronal cells. Pannexin-1 channel opening, frequently together with the activation of purinergic receptors by extracellular ATP, is reported to have a great implication in diverse pathological conditions, including ischemia, trauma, HIV infection, inflammation, migraine, and cancer cell growth.

Specifications

• Antigen: Pannexin-1/PANX1
• Applications: Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: Q96RD7
• Gene Symbols: PANX1, MRS1, PX1
• Host Species: Rabbit
• Immunogen: GST-tagged recombinant human Pannexin-1/PANX1 C-terminal fragment.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Neuroscience
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_056183
• Test Specificity: Expected to react with both spliced isoforms reported by UniProt (Q96RD7-1, Q96RD7-2).
• Target Species: Human, Mouse, Rat
• Content And Storage: 2°C to 8°C for one year

For Research Use Only