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PARP Mouse anti-Human, Clone: 194C1439, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141020

Catalog No. 01-676-438


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Description

Description

Suggested positive control: camptothecin treated HL-60 (12 hr).

The poly (ADP-ribose) polymerase (PARP) is involved in cell recovery from DNA damage, such as methylation of N3-adenine, which activates the base excision repair process. PARP [Poly (ADP-ribose) polymerase] is a 116 kDa nuclear chromatin-associated enzyme that is cleaved during apoptosis by caspase-3 into a 24 kDa fragment containing the DNA binding domain and an 89 kDa fragment containing the catalytic and automodification domains. The 24 kDa-fragment irreversibly bind to DNA and may contribute to the irreversibility of apoptosis by blocking the access of DNA repair enzymes to DNA strand breaks.
Specifications

Specifications

PARP
Monoclonal
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
P09874
Cleavage specific PARP
Mouse
IgG2b, kappa
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
142
Flow Cytometry, Western Blot
194C1439
Unconjugated
PARP1
Liquid
PARP1
Synthetic peptide corresponding to residues near the 214/215-cleavage site of human PARP.
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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