PARP Mouse anti-Human, Unlabeled, Clone: 7D3-6, BD

Catalog No.	Quantity
BDB551025	150 μg
BDB551024	50 μg

Catalog No. BDB551025 Supplier BD Biosciences Supplier No. 551025

Description

Includes

Purified Mouse Anti-Human PARP, Jurkat Cell Lysate

Mouse Monoclonal Antibody

PARP [Poly(ADP-ribose) polymerase] is a 116kDa nuclear chromatin-associated enzyme that catalyzes the transfer of ADP-ribose units from NAD+ to a variety of nuclear proteins including topoisomerases, histones, and PARP itself. The catalytic activity of PARP is increased in nonapoptotic cells following DNA damage, and PARP is thought to play an important role in mediating the normal cellular response to DNA damage. Additionally, PARP is a target of the caspase protease activity associated with apoptosis. During apoptosis, PARP is cleaved from the 116kDa intact form into 85kDa and 25kDa fragments. This process separates the amino-terminal DNA-binding domain of the enzyme from the carboxy-terminal catalytic domain resulting in the loss of normal PARP function. Although the role of PARP in apoptosis remains to be elucidated, PARP cleavage is considered to be a marker of apoptosis.

Host Species: Mouse
Clone: 7D3-6
Isotype: IgG1
Species Reactivity: Human
Immunogen: Purified human PARP

Flow Cytometry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: PARP
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 7D3-6
• Concentration: 0.25mg/mL
• Conjugate: Unconjugated
• Host Species: Mouse
• Immunogen: Purified human PARP
• Purification Method: Affinity Purified
• Quantity: 150 μg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at -20°C.
• Isotype: IgG1

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.