PARP Mouse, Unlabeled, Clone: C2-10, BD

Catalog No.	Quantity
BDB556362	0.1 mL

Catalog No. BDB556362 Supplier BD Biosciences Supplier No. 556362

Description

Mouse Monoclonal Antibody

PARP [Poly(ADP-Ribose) Polymerase] is a 113kDa nuclear chromatin associated enzyme that catalyzes the transfer of ADP-ribose units from NAD+ to a variety of nuclear proteins including topoisomerases, histones, and PARP itself. The catalytic activity of PARP is increased in nonapoptotic cells following DNA damage, and PARP is thought to play an important role in mediating the normal cellular reponse to DNA damage and is a target of the caspase protease activity associated with apoptosis. During apoptosis, PARP is cleaved from a 113kDa intact form into 89kDa and 24kDa fragments. This process separates the amino-terminal DNA-binding domain of the enzyme from the C-terminal catalytic domain resulting in the loss of normal PARP function. Although the role of PARP in apoptosis remains to be elucidated, PARP cleavage is considered to be a marker of apoptosis. This antibody has been reported to recognize an epitope located within the DNA-binding domain of the enzyme.

Host Species: Mouse
Clone: C2-10
Isotype: IgG1
Species Reactivity: Human
Immunogen: Cow PARP (full-length; thymus derived)

Immunofluorescence, Western Blotting

Specifications

• Antigen: PARP
• Applications: Western Blot
• Classification: Monoclonal
• Clone: C2-10
• Conjugate: Unconjugated
• Description: Poly (ADP-Ribose) Polymerase
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Cow PARP (full-length; thymus derived)
• Quantity: 0.1 mL
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Bovine, Hamster, Human, Mouse
• Content And Storage: Store undiluted at 4°C
• Form: Ascites
• Isotype: IgG1

For Research Use Only.