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PAX-5 Rat, Alexa Fluor 647, Clone: 1H9, BD

Catalog No. BDB562814 Shop All BD Biosciences Products
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BDB562814 50 μg
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Catalog No. BDB562814 Supplier BD Biosciences Supplier No. 562814

Description

Rat Monoclonal Antibody

The 1H9 monoclonal antibody clone specifically binds to human and mouse Paired box protein Pax-5. Pax-5 is a ∽50 kDa protein that is also known as B-cell-specific transcription factor and B cell specific activator protein (BSAP). Pax-5 is a member of the paired box (Pax) family of transcription factors. It is expressed in pro-B, pre-B and mature B cells. Through the Groucho family of co-repressors, Pax-5 likely functions as a transcriptional repressor of non-B-lymphoid genes during the B cell commitment process. In the early stages of B cell development, Pax-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20 and maintains B cell identity. Pax-5 suppression is involved in the upregulation of Blimp-1 leading to the development of Pax-5-negative plasma cells. Pax-5 mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis. Expression then shifts to the fetal liver and correlates with the onset of B lymphopoiesis. Altered forms and expression patterns of Pax-5 have been associated with some lymphoid and nonlymphoid cancers.

TRUSTED_SUSTAINABILITY

Specifications

Antigen PAX-5
Applications Flow Cytometry
Classification Monoclonal
Clone 1H9
Concentration 0.2mg/mL
Conjugate Alexa Fluor 647
Description Pax5, PAX5, KLP, BSAP, EBB-1; B-cell-specific transcription factor
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Recombinant Mouse Pax-5 protein containing aa 154-284
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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