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Pax-5 Mouse, Unlabeled, Clone: 24, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610863

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Catalog No. BDB610863


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Description

Description

There are at least nine members of the paired box (Pax) gene family whose protein products are transcription factors involved in development. The conserved paired box DNA-binding domain is found in the N-terminal region of Pax proteins. An octomer and homeodomain sequence are conserved in the center of the proteins. The Ser/Thr/Pro-rich region in the C-terminal portion contains a conserved 100 amino acid transactivating domain. One of the best studied Pax family members, Pax 5, is a B cell specific activator protein (BSAP). In the early stages of B cell development, Pax-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20. Pax-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. Interestingly, Pax-5 mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis. Expression then shifts to the fetal liver and correlates with the onset of B lymphopoiesis. Pax-5 has been found to be important in both B cell and nervous system development.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

Pax-5
24
Unconjugated
Affinity Purified
Human Pax-5 aa. 151-306
150μg
Cell Biology
Primary
Human, Murine
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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