Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Pax-5 Mouse, Unlabeled, Clone: 24, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610863

 View more versions of this product

Catalog No. BDB610863

Add to cart



There are at least nine members of the paired box (Pax) gene family whose protein products are transcription factors involved in development. The conserved paired box DNA-binding domain is found in the N-terminal region of Pax proteins. An octomer and homeodomain sequence are conserved in the center of the proteins. The Ser/Thr/Pro-rich region in the C-terminal portion contains a conserved 100 amino acid transactivating domain. One of the best studied Pax family members, Pax 5, is a B cell specific activator protein (BSAP). In the early stages of B cell development, Pax-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20. Pax-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. Interestingly, Pax-5 mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis. Expression then shifts to the fetal liver and correlates with the onset of B lymphopoiesis. Pax-5 has been found to be important in both B cell and nervous system development.

Immunofluorescence, Immunoprecipitation, Western Blotting



Affinity Purified
Human Pax-5 aa. 151-306
Cell Biology
Human, Murine
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only.