Paxillin Mouse, Unlabeled, Clone: 349, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 612405
A number of cytoskeletal proteins are tyrosine phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts. One of these is the 68kDa paxillin protein. Paxillin is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers. It is also present in the focal adhesions of Madin-Darby canine kidney epithelial cells, but is absent from the cell adherens junctions of these cells. Paxillin purified from chicken gizzard migrates as a diffuse band on SDS-PAGE with molecular weight of 65-70kDa. It binds to the rod domain of vinculin, another focal adhesion protein. It is thought that phosphorylation of paxillin may have a role in that disassembly of focal adhesions and stress fibers during transformation.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
|Chicken Paxillin aa. 1-557|
|Canine, Chicken, Human, Murine, Rat|
|Aqueous buffered solution containing glycerol and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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