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Paxillin Mouse, Unlabeled, Clone: 349, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610051

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Catalog No. BDB610051


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Description

Description

A number of cytoskeletal proteins are tyrosine phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts. One of these is the 68 kDa paxillin protein. Paxillin is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers. It is also present in the focal adhesions of Madin-Darby canine kidney epithelial cells, but is absent from the cell adherens junctions of these cells. Paxillin purified from chicken gizzard migrates as a diffuse band on SDS-PAGE with molecular weight of 65-70 kDa. It binds to the rod domain of vinculin, another focal adhesion protein. It is thought that phosphorylation of paxillin may have a role in that disassembly of focal adhesions and stress fibers during transformation.
Specifications

Specifications

Paxillin
349
Unconjugated
Affinity Purified
Chicken Paxillin aa. 1 to 557
50μg
Cell Biology
Primary
Canine, Chicken, Human, Murine, Rat
Western Blot
1.0mg/mL
Aqueous buffered solution containing glycerol and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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