PBK Mouse, Unlabeled, Clone: 31, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 612171
Mitogen activated protein (MAP) kinase signal transduction pathways mediate the effects of various extracellular stimuli on biological processes such as proliferation, differentiation, and death. The p38 MAP kinases are activated by dual phosphorylation on Thr and Tyr within the motif Thr-Gly-Tyr located in kinase subdomain VIII. Activation of p38 MAPK is mediated specifically by the MAP kinase kinases, MKK3 and MKK6. PBK is a PDZ-binding Ser-Thr kinase related to the MKK3/6 MAPKK family. PBK was also identified as T-LAK celloriginated protein kinase (TOPK) and spermatogenesis-related protein kinase (SPK). PBK contains the conserved dual specficity active site sequence (D-X-K-X-X-N) at amino acids 174 to 179, and a C terminal ETDV motif that binds PDZ domains. The mRNA expression of PBK is reportedly highest in placenta, and lower in heart and pancreas. In mitotic cells, PBK is phosphorylated and enzymatically active, and in vitro, PBK is phosphorylated by Cdc2/cyclin B. PBK can bind to the PDZ domain-containing protein, Dlg, and can phosphorylate p38 MAPK. Thus, PBK is a MAPKK family member that may be important for regulation of PDZ domain proteins during mitosis.
|Human PBK aa. 191-322|
|Human, Murine, Rat|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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