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PCMT-I/II Mouse, Unlabeled, Clone: 4, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610772

Catalog No. BDB610772

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.



PCMT-II (Protein Carboxyl Methyl Transferase), or L-isoaspartate (D-aspartate) O-methyltransferase, is a cytosolic enzyme that is expressed in all tissues as well as in bacteria. Interestingly, PCMT-II is highly expressed in the brain. It recognizes damaged proteins that result from deamidation, isomerization, and racemization reactions. These proteins contain L-isoaspartyl and D-aspartyl residues and can have abnormal configurations that result in anomalous or loss of function. PCMT-II catalyzes the first step of the conversion of these unusual residues to normal L-aspartyl residues. This mechanism prevents the accumulation of aberrant proteins in aging cells. Pcmt-1 knock-out mice display growth retardation and a seizure disorder that results in death at an average age of 42 days. Thus, PCMT-II is necessary for growth and nervous system function. The immunogen region from human PCMT-II used to generate this antibody has been reported to be identical to the region in PCMT-I.

Immunofluorescence, Immunoprecipitation, Western Blotting



Bovine, Canine, Human
Immunofluorescence, Western Blot
Affinity Purified
Human PCMT-II aa. 10-211
Cell Biology
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