PCMT-I/II Mouse, Unlabeled, Clone: 4, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610772
PCMT-II (Protein Carboxyl Methyl Transferase), or L-isoaspartate (D-aspartate) O-methyltransferase, is a cytosolic enzyme that is expressed in all tissues as well as in bacteria. Interestingly, PCMT-II is highly expressed in the brain. It recognizes damaged proteins that result from deamidation, isomerization, and racemization reactions. These proteins contain L-isoaspartyl and D-aspartyl residues and can have abnormal configurations that result in anomalous or loss of function. PCMT-II catalyzes the first step of the conversion of these unusual residues to normal L-aspartyl residues. This mechanism prevents the accumulation of aberrant proteins in aging cells. Pcmt-1 knock-out mice display growth retardation and a seizure disorder that results in death at an average age of 42 days. Thus, PCMT-II is necessary for growth and nervous system function. The immunogen region from human PCMT-II used to generate this antibody has been reported to be identical to the region in PCMT-I.
Immunofluorescence, Immunoprecipitation, Western Blotting
|Bovine, Canine, Human|
|Immunofluorescence, Western Blot|
|Human PCMT-II aa. 10-211|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok