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protein-L-isoaspartate (D-aspartate) O-methyltransferase, Mouse, Clone: 4G9, Abnova™

Catalog No. 89015836 Shop All Abnova Corporation Products
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89-015-836 100 μg
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Catalog No. 89-015-836 Supplier Abnova Corporation Supplier No. H00005110M01
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Description

Mouse monoclonal antibody raised against a full-length recombinant PCMT1.

Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM

Sequence: MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATISAPHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDPTLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPAGGNQMLEQYDKLQDGSIKMKPLMGVIYVPLTDKEKQWSRDEL

Specifications

Antigen protein-L-isoaspartate (D-aspartate) O-methyltransferase
Applications ELISA, Western Blot
Classification Monoclonal
Clone 4G9
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against a full length recombinant PCMT1.
Formulation PBS with no preservative; pH 7.4
Gene PCMT1
Gene Accession No. BC007501
Gene Symbols PCMT1
Host Species Mouse
Immunogen PCMT1 (AAH07501.1, 1 a.a. ∼ 228 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5110
Target Species Human, Rat
Content And Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Product Type Antibody
Isotype IgG2a κ
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