PDH Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA526656

Catalog No. PIPA526656

Description

This antibody is predicted to react with bovine, mouse, porcine, non-human primate and rat based on sequence homology.

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome.

Specifications

• Antigen: PDH
• Classification: Polyclonal
• Gene: PDHA1
• Gene Alias: PDHA, PDHCE1A, PHE1A, PDHE1-A type I, pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, pyruvate dehydrogenase complex, E1-alpha polypeptide 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5160
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: P08559
• Gene Symbols: PDHA1
• Immunogen: KLH conjugated synthetic peptide between 226-255 amino acids from the central region of human PDHA1
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG