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PDPK1 (pS241) Mouse, PE, Clone: J66-653.44.17, BD

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BDB560092 50 Tests
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Catalog No. BDB560092 Supplier BD Biosciences Supplier No. 560092
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Description

Mouse Monoclonal Antibody

The serine/threonine kinase 3- Phosphoinositide- Dependent Protein Kinase-1 (PDPK1, also known as PDK1) contributes to the activation of many important kinases in the insulin and IGF-1 signaling pathways. It acts downstream of phosphatidylinositol 3-kinase (PI3-kinase) to phosphorylate residues in the activation loops of many cellular kinases, including protein kinase B (PKB/Akt), PKC isoforms, p70 S6 kinase, and PDPK1 itself. The autophosphorylation of PDPK1 at serine 241 (S241) has recently been suggested to play a role in the regulation of PDPK1. It has been proposed that PDPK1 activity plays a key role in the regulation of various cellular events such as cell proliferation, differentiation, and apoptosis.

The J666-653.44.17 monoclonal antibody recognizes the phosphorylated S241 in the activation loop of human PDPK1. The orthologous phosphorylation site in mouse and rat PDPK1 is S244.

TRUSTED_SUSTAINABILITY

Specifications

Antigen PDPK1 (pS241)
Applications Flow Cytometry
Classification Monoclonal
Clone J66-653.44.17
Conjugate PE
Description PDK1 (pS241), PKB Kinase (pS241)
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human PDPK1 Peptide
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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