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Perforin Mouse anti-Human, Unlabeled, Clone: ΔG9, BD

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BDB556434 0.1 mg
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Catalog No. BDB556434 Supplier BD Biosciences Supplier No. 556434
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Description

Mouse Monoclonal Antibody

Perforin has a key role in cell-mediated cytotoxicity. It is a 70kDa cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. CTLs are involved in eliminating virally infected cells, in anti-tumor immune responses, in allograft rejections, and in some autoimmune diseases. NK cells are important for tumor surveillance and destruction and are involved in allograft rejections. Cytotoxic cells release the contents of their cytotoxic granules, including perforin upon recognition of their target cell. In the presence of calcium, perforin forms transmembrane channels or pores in the membrane of the target cell leading to a cell death that resembles apoptosis. The ability to detect perforin-positive cells with specific antibody should be useful in identifying and understanding perforin-mediated reactions. Clone δG9 reacts with human and bovine perforin. It does not cross-react with mouse perforin. Purified granules from the human lymphoma cell line YT were used as immunogen. Clone δG9 was initially characterized by immunoprecipitation and immunohistochemistry of frozen tissue sections. The antibody stains scattered lymphocytes in red pulp of spleen, and scattered infiltrated lymphocytes in lymphoma.

Host Species: Mouse
Clone: δG9
Isotype: IgG2b, κ
Species Reactivity: Human
Immunogen: Purified Granules from the Human Lymphoma Cell Line YT

Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation

TRUSTED_SUSTAINABILITY

Specifications

Antigen Perforin
Applications Flow Cytometry
Classification Monoclonal
Clone ΔG9
Concentration 0.5mg/mL
Conjugate Unconjugated
Description PRF1; P1; PERF; PFN1; PFP; Perforin-1; Cytolysin; FLH2; HPLH2
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Purified Granules from the Human Lymphoma Cell Line YT
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Bovine, Human
Content And Storage Store undiluted at 4°C
Isotype IgG2b κ
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For Research Use Only.

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