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Perforin Mouse anti-Human, PE, Clone: ΔG9, BD

Catalog No. BDB556437 Shop All BD Biosciences Products
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BDB556437 100 Tests
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Description

Includes

PE Mouse Anti-Human Perforin, PE Mouse IgG2b, κ Isotype Control (anti-dansyl)

Mouse Monoclonal Antibody

Perforin has a key role in cell-mediated cytotoxicity. It is a 70kDa cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. CTLs are involved in eliminating virally infected cells, in anti-tumor immune responses, in allograft rejections, and in some autoimmune diseases. Cytotoxic cells release the contents of their cytotoxic granules, including perforin upon recognition of their target cell. In the presence of calcium, perforin forms transmembrane channels or pores in the membrane of the target cell leading to a cell death that resembles apoptosis. The ability to detect perforin-positive cells with specific antibody should be useful in identifying and understanding perforin-mediated reactions. Clone δG9 reacts with human and bovine perforin. It does not cross-react with mouse perforin. Clone δG9 was initially characterized by immunoprecipitation and immunohistochemistry of frozen tissue sections, and has also been published for flow cytometric analysis. Clone 27-35 is an isotype control monoclonal antibody specific for hapten dansyl (5-[dimethylamino] naphthalene-1-sulfonyl). This hapten is not expressed on human cells or human cell lines.

Host Species: Mouse
Clone: δG9, 27-35
Isotype: IgG2b, κ
Species Reactivity: Human
Immunogen: Purified Granules from the Human Lymphoma Cell Line YT

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen Perforin
Applications Flow Cytometry
Classification Monoclonal
Clone ΔG9
Conjugate PE
Host Species Mouse
Immunogen Purified Granules from the Human Lymphoma Cell Line YT
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b
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For Research Use Only.

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