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Pericentrin Mouse anti-Mouse, Unlabeled, Clone: 30, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611814

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Catalog No. BDB611814


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Description

Description

Centrosomes and other microtubule-organizing centers are a diverse group of organelles that nucleate and organize microtubules for many celllular processes, such as mitotic spindle formation, organelle tranpsort, and protein localization. Pericentrin is a protein in the pericentriolar material, a filamentous matrix surrounding centrioles, which can organize microtubule spindle formation. The structure of pericentrin includes multiple α-helical domains that form coiled-coil domains separated by non-helical, non-coiled regions. It is found in a 3MDa-complex that includes γ-tubulin, a form of tubulin that nucleates microtubule formation at the centrosome. Pericentrin exhibits the highest expression in embryonic mouse kidney, thymus, and liver. Injection of pericentrin antibodies in Xenopus oocytes disrupts mitotic and meiotic divisions and blocks microtubule aster formation. In addition, dynein transports both pericentrin and γ-tubulin to centrosomes along microtubules in Xenopus oocyte extracts. Thus, the complex of pericentrin and γ-tubulin may be recruited to the centrosome by dynein, where the complex becomes anchored to the centrosome for microtubule nucleating activity.

Host Species: Mouse
Clone: 30
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Mouse pericentrin aa. 1692-1814

Immunofluorescence, Western Blotting

Specifications

Specifications

Pericentrin
30
Unconjugated
Affinity Purified
Mouse pericentrin aa. 1692-1814
50μg
Cell Biology
Primary
Murine
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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