PEX5 Mouse anti-Mouse, Unlabeled, Clone: 50, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611594
Pex genes encode proteins called peroxins that are involved in protein transport from the cytoplasm to peroxisomes. Import of peroxisomal matrix proteins depends on two peroxisomal targeting signals, PTS1 and PTS2. PTS1 is a C-terminal tripeptide of Ser-Lys-Leu and PTS2 is a cleavable N-terminal signal. Two peroxin receptors, PEX5 and PEX7, specifically bind peroxisomal matrix proteins that contain the PTS1 and PTS2 signal, respectively. Both receptors have repetitive motifs that belong to structural families. PEX5 contains seven tetratricopeptide repeats (TPR), while PEX7 has six WD motifs. PEX5 is bound by the SH3 domain of the membrane-bound peroxin PEX13. This may facilitate docking of PEX5 peroxisome protein complexes to the peroxisomal membrane. In addition, PEX12 and PEX14 bind PEX5 and may act downstream of the docking process to promote protein import. After PEX5-mediated import of the peroxisomal matrix protein, PEX4 recycles PEX5 from the peroxisome to the cytoplasm. The ubiquitous expression of PEX5 indicates that PEX5-mediated import of PTS1-containing proteins is commonly used by a variety of cell types.
Host Species: Mouse
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse PE5 aa. 246-361
Immunofluorescence, Western Blotting
|Immunofluorescence, Western Blot|
|Mouse PE5 aa. 246-361|
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