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MilliporeSigma™ anti-PGC-1alpha, Polyclonal

Catalog No. ST1204100UL Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ST1204100UL 100 μL Unconjugated
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Catalog No. ST1204100UL Supplier MilliporeSigma™ Supplier No. ST1204100UL

Description

Rabbit Polyclonal Antibody

Specifically detects PGC-1α Clone: in Human, Mouse, Rat samples, and it is validated for Immunoprecipitation

PGC-1α is a co-activator of PPARα, PPARγ, and other transcription factors that regulate the transcriptonal program of adaptive thermogenesis in brown adipose tissue, hepatic/renal gluconeogenesis, and muscle fiber type switching. The full length protein is detected at 113kDa and is induced in BAT by cold exposure, in liver and kidney by fasting, and in skeletal muscle by exercise. Alternative splicing of the full length gene produces a 270 aa N-terminal splice variant that migrates at∽38kDa and is induced by the same physiological signals which induce expression of the full length protein. The N-terminal PGC-1α splice variant is also subject to post translational modifications which alter its migration and apparent molecular weight.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PGC-1α
Applications Immunoprecipitation
Classification Polyclonal
Conjugate Unconjugated
Formulation In 50mM PBS
Host Species Rabbit
Immunogen A recombinant protein consisting of amino acids 1-120 of mouse PGC-1α
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽113kDa PGC-1α protein in BAT cells.
Target Species Human, Mouse, Rat
Content And Storage ≤ -70°C
Form Purified
Isotype IgG
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For Research Use Only

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