MilliporeSigma™ anti-PGC-1alpha, Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ ST1204100UL

Catalog No. ST1204100UL

Description

Specifically detects PGC-1α Clone: in Human, Mouse, Rat samples, and it is validated for Immunoprecipitation

PGC-1α is a co-activator of PPARα, PPARγ, and other transcription factors that regulate the transcriptonal program of adaptive thermogenesis in brown adipose tissue, hepatic/renal gluconeogenesis, and muscle fiber type switching. The full length protein is detected at 113kDa and is induced in BAT by cold exposure, in liver and kidney by fasting, and in skeletal muscle by exercise. Alternative splicing of the full length gene produces a 270 aa N-terminal splice variant that migrates at~38kDa and is induced by the same physiological signals which induce expression of the full length protein. The N-terminal PGC-1α splice variant is also subject to post translational modifications which alter its migration and apparent molecular weight.

Specifications

• Antigen: PGC-1α
• Conjugate: Unconjugated
• Format: Purified
• Immunogen: A recombinant protein consisting of amino acids 1-120 of mouse PGC-1α
• Quantity: 100μL
• Storage Requirements: ≤ -70°C
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human, Murine, Rat

• Applications: Immunoprecipitation
• Formulation: In 50mM PBS
• Host Species: Rabbit
• Isotype: IgG
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽113kDa PGC-1α protein in BAT cells.

For Research Use Only