MilliporeSigma™ anti-PGC-1alpha, Polyclonal

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ST1204100UL

Catalog No. ST1204100UL

Description

Specifically detects PGC-1α Clone: in Human, Mouse, Rat samples, and it is validated for Immunoprecipitation

PGC-1α is a co-activator of PPARα, PPARγ, and other transcription factors that regulate the transcriptonal program of adaptive thermogenesis in brown adipose tissue, hepatic/renal gluconeogenesis, and muscle fiber type switching. The full length protein is detected at 113kDa and is induced in BAT by cold exposure, in liver and kidney by fasting, and in skeletal muscle by exercise. Alternative splicing of the full length gene produces a 270 aa N-terminal splice variant that migrates at∽38kDa and is induced by the same physiological signals which induce expression of the full length protein. The N-terminal PGC-1α splice variant is also subject to post translational modifications which alter its migration and apparent molecular weight.

Specifications

• Antigen: PGC-1α
• Classification: Polyclonal
• Formulation: In 50mM PBS
• Immunogen: A recombinant protein consisting of amino acids 1-120 of mouse PGC-1α
• Regulatory Status: RUO
• Test Specificity: Recognizes the ∽113kDa PGC-1α protein in BAT cells.
• Content And Storage: ≤ -70°C
• Isotype: IgG

• Applications: Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Form: Purified

For Research Use Only