Phospho-DARPP-32 (Thr75) Rabbit anti-Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14611
This antibody is predicted to react with bovine, canine, chicken, human, mouse and non-human primate based on 100% sequence homology. In Western blot, this antibody detects an ~32 kDa protein representing the Phospho-Thr75 DARPP-32 protein.DARPP-32 is a dopamine (DA) and cAMP-regulated ~32 kDa phosphoprotein that is associated with dopaminoceptive neurons (Fienberg et al., 1998). The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA (Bibb et al., 1999). Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac (Maldve et al., 2002; Lindskog et al., 2002; Svenningsson et al., 2002).
|0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|Dopamine- and cAMP-regulated neuronal phosphoprotein|
|-20° C, Avoid Freeze/Thaw Cycles|
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr75 of rat PPP1R1B conjugated to KLH|
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