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MilliporeSigma™ anti-phospho Mis18-binding protein 1 (Thr702), Polyclonal

Catalog No. ABE1847MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ABE1847MI 100 μg Unconjugated
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Catalog No. ABE1847MI Supplier MilliporeSigma™ Supplier No. ABE1847
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Description

Rabbit Polyclonal Antibody

Specifically detects phospho Mis18-binding protein 1 (Thr702) Clone: in Human samples, and it is validated for Dot Blot, Immunocytochemistry, Western Blotting

Mis18-binding protein 1 (UniProt Q6P0N0; also known as hsKNL-2, Kinetochore null 2 homolog, Kinetochore-associated protein KNL-2 homolog, P243, Putative protein p243 which interacts with transcription factor Sp1) is encoded by the MIS18BP1 (also known as C14orf106, KIAA1903, KNL2, M18BP1) gene (Gene ID 55320) in human. Mis18-binding protein 1 is a component of the Mis18 complex (Mis18α, Mis18β, and M18BP1/KNL2) that plays a role in mediating cell cycle-dependent deposition/incorporation of the histone H3 variant CENP-A at the centromeres. CENP-A incorporation is carried out by at least two sets of events, the Mis18 complex must first localize to centromeres at the onset of anaphase, HJURP-mediated CENP-A deposition then occurs during G1. Polo-like kinase 1 (Plk1) is shown to phosphorylate M18BP1 on Thr702 and plays an important role in promoting Mis18 complex centromere localization.
TRUSTED_SUSTAINABILITY

Specifications

Antigen phospho Mis18-binding protein 1 (Thr702)
Applications Dot Blot, Immunocytochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation Purified rabbit polyclonal antibody in PBS with 0.05% sodium azide and 30% glycerol.
Gene Accession No. Q6P0N0
Gene Symbols MIS18BP1, C14orf106, KIAA1903, KNL2, M18BP1
Host Species Rabbit
Immunogen Linear peptide corresponding to a human M18BP1 sequence containing phosphorylated Thr702.
Purification Method Affinity Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics, Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_060823
Test Specificity Specifically reacts with the immunogen peptide, but not the corresponding non-phosphorylated sequence, by dot blot analysis. Phosphorylation site is not present in the spliced isoform 2 of human Mis18-binding protein 1/M18BP1.
Target Species Human
Content And Storage −20°C for one year
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For Research Use Only

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