NF-H Mouse anti-Bovine, Chicken, Equine, Human, Mouse, Porcine, Rat, Clone: NAP4, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA110041
This antibody recognizes phosphorylated NF-H KSP (lysine-serine-proline) type sequences.Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predomitly of three major proteins called NF-L, NF-M and NF-H. NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDA, with some variability across species boundaries. Antibodies to NF-H are useful for identifying neuronal cells and their proceses in tissue sections and in tissue culture. NF-H antibodies can also be useful in the diagnostics of neurofilament accumulations seen in many neurological diseases, such as Amyothrophic lateral sclerosis (also known as Lou Gehrig′s disease) and Alzheimer′s disease. NAP4 is one of numerous antibodies which reacts preferentially with the phosphorylated forms of NF-H. These forms have an apparent sized determined from SDS-PAGE gels at about 40 kDs greater than the non-phosphorylated forms. Interestingly the phosphorylated forms of NF-H are normally restricted to axons, while less phosphorylated forms are found in dendrites. However in numerous damage and disease states, phosphorylated NF-H can be detected in NAP4 in dendritic and perikaryal neurofilaments.
|Native NF-H purified from bovine spinal cord|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|100064328, 100156492, 24587, 380684, 417020, 4744, 528842|
|Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot|
|PBS with 50% glycerol and 5mM sodium azide|
|P12036, P12037, P16884, P19246|
|NFH, NHC, NF 200 kD|
|Bovine, Chicken, Equine, Human, Mouse, Porcine, Rat|
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