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Phospho-c-Raf (Thr269) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512778

Catalog No. PIPA512778


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Description

Description

This antibody is predicted to react with rat based on sequence homology.

Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
Specifications

Specifications

Phospho-c-Raf (Thr269)
Polyclonal
PBS with 0.09% sodium azide
P04049
RAF proto-oncogene serine/threonine-protein kinase; Raf-1; C-RAF; cRaf; RAF
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5894
Dot Blot
Unconjugated
RAF1
Liquid
RAF1
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T269 of human RAF1
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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