Phospho-RBL1 (Ser975) Rabbit anti-Human, Polyclonal, Invitrogen™

Catalog No.	Quantity
PIPA512677	400 μL

Catalog No. PIPA512677 Supplier Thermo Scientific Supplier No. PA512677

Description

Rabbit Polyclonal Antibody

RB-like 1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and RB-like 1 can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that RB-like 1 may also be a tumor suppressor.

Specifications

• Antigen: Phospho-RBL1 (Ser975)
• Applications: Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RBL1
• Gene Accession No.: P28749
• Gene Alias: Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; PRB1; P107; RBL1;
• Gene Symbols: RBL1
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S975 of human Rb-like-1
• Purification Method: Antigen affinity chromatography
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5933
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG