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MilliporeSigma™ anti-PhosphoDetect ATM (pSer1981) Clone: 10H11.E12,

Catalog No. DR100250UG Shop All MilliporeSigma Products
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Quantity:
50 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
DR100250UG 50 μg Unconjugated
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Catalog No. DR100250UG Supplier MilliporeSigma™ Supplier No. DR100250UG

Description

Mouse Monoclonal Antibody

Specifically detects ATM (pSer1981) Clone: 10H11.E12 in Human, Mouse samples, and it is validated for Immunocytochemistry

ATM (ataxia telangiectasia mutated, ACC# NP_000042) is a member of the PI-3/PI-4 kinase family and is a central mediator of the cellular response to DNA damage and cellular stress. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. ATM is a regulator of numerous downstream proteins, including the tumor suppressor proteins, p53 and BRCA1, the checkpoint kinase, CHK2, the checkpoint proteins RAD17 and RAD9, and the DNA repair protein NBS1. ATM and the functionally related ATR kinase are thought to be master regulators of cell cycle checkpoint signaling pathways that are required for the cellular response to DNA damage and as well as genome stability. Activation of ATM in response to DNA damage requires intermolecular autophosphorylation of Ser1981 and dimer dissociation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATM (pSer1981)
Applications Immunocytochemistry
Classification Monoclonal
Clone 10H11.E12
Conjugate Unconjugated
Formulation In PBS.
Host Species Mouse
Immunogen a synthetic phosphopeptide (SLAFEEGpSQSTTISS) corresponding to amino acids 1974-1988 surrounding the Ser1981 phosphorylation site of human ATM
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽370kDa ATM protein phosphorylated on Ser1981 in camptothecin-treated HeLa cells. Sold under license of U.S. Patent 7,108,992.
Target Species Human, Mouse
Content And Storage −20°C
Form Purified
Isotype IgG1
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For Research Use Only

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