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MilliporeSigma™ anti-PhosphoDetect EGFR (pTyr1068), Polyclonal

Catalog No. 32486710T Shop All MilliporeSigma Products
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10 Tests
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
32-486-710T 10 Tests Unconjugated
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Catalog No. 32-486-710T Supplier MilliporeSigma™ Supplier No. 32486710T
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Description

Rabbit Polyclonal Antibody

Specifically detects PhosphoDetect™ EGFR (pTyr1068) Clone: in Chicken, Human, Mouse, Rat samples, and it is validated for Immuno Blotting

Epidermal Growth Factor (EGF) is responsible for a variety of biological effects including mitogenesis and differentiation. The EGF receptor (EGFR) has three domains: the extracellular, transmembrane, and cytoplasmic domains. Upon binding of EGF to the extracellular domain, dimerization of the receptor occurs and the cytoplasmic domains display tyrosine kinnase activity. This leads to autophosphorylation of the∽170kDa glycoprotein on various residues within the cytoplasmic domain as well as phosphorylation of intracellular substrates. Tyr1068 is an autophosphorylation site in EGFR. The SH2 domain of Grb2 binds to Tyr1068 of EGFR in the multimeric complex EGFR-Grb2-mSos1 that is formed upon stimulation of EGFR with EGF.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PhosphoDetect™ EGFR (pTyr1068)
Applications Immunoblot
Classification Polyclonal
Conjugate Unconjugated
Formulation In Dulbecco's PBS, 1mg/mL BSA, 50% glycerol, pH 7.4.
Host Species Rabbit
Immunogen a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr1068 phosphorylation site of human EGFR
Quantity 10 Tests
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽185kDa EGFR protein phosphorylated at Tyr1068. Note: 1 T = 1 test. Sufficient for 10 Western miniblots.
Target Species Chicken, Human, Mouse, Rat
Content And Storage −20°C
Form Purified
Isotype IgG
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