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MilliporeSigma™ anti-PhosphoDetect EGFR (pTyr845), Polyclonal

Catalog No. 32486510T Shop All MilliporeSigma Products
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10 Tests
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
32-486-510T 10 Tests Unconjugated
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Catalog No. 32-486-510T Supplier MilliporeSigma™ Supplier No. 32486510T
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Description

Rabbit Polyclonal Antibody

Specifically detects PhosphoDetect™ EGFR (pTyr845) Clone: in Human samples, and it is validated for Immuno Blotting

Epidermal Growth Factor (EGF) is responsible for a variety of biological effects including mitogenesis and differentiation. The EGF receptor (EGFR) has three domains: the extracellular, transmembrane, and cytoplasmic domain. Upon the binding of EGF to the extracellular domain, dimerization of the receptor occurs and the cytoplasmic domain displays tyrosine kinase activity. This leads to the autophosphorylation of the∽170kDa glycoprotein on various residues within the cytoplasmic domain as well as the phosphorylation of intracellular substrates. Tyr845 is an autophosphorylation site within EGFR. Phosphorylation of tyrosine 845 is mediated by non-receptor tyrosine kinase c-Src.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PhosphoDetect™ EGFR (pTyr845)
Applications Immunoblot
Classification Polyclonal
Conjugate Unconjugated
Formulation In Dulbecco's PBS (w/o Mg2+ and Ca2+), 1mg/mL BSA, 50% glycerol, pH 7.4.
Host Species Rabbit
Immunogen a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr845 phosphorylation site of human EGFR
Quantity 10 Tests
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽170kDa EGFR protein phosphorylated at Tyr845 in EGF-treated A431 cells. Note: 1 T = 1 test. Sufficient for 10 Western miniblots.
Target Species Human
Content And Storage ≤ -70°C
Form Purified
Isotype IgG
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