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MilliporeSigma™ anti-PhosphoDetect Insulin Receptor (pTyr1162/1163), Polyclonal

Catalog No. 40770710T Shop All MilliporeSigma Products
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10 Tests
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
40-770-710T 10 Tests Unconjugated
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Catalog No. 40-770-710T Supplier MilliporeSigma™ Supplier No. 40770710T
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Description

Rabbit Polyclonal Antibody

Specifically detects PhosphoDetect™ Insulin Receptor (pTyr1162/1163) Clone: in Human samples, and it is validated for ELISA, Immunocytochemistry, Immuno Blotting

Insulin initiates its effects on cells through interaction with high-affinity cell surface glycoprotein receptors consisting of twoα (∽135kDa) and twoβ (∽95kDa) subunits linked by disulfide bonds. Theα subunits bind insulin and theβ subunits become phosphorylated in response to insulin. Insulin-dependent phosphorylation occurs at multiple sites near the carboxyl terminus and in the kinase domain. The receptor protein tyrosine kinase has been implicated as the mediator of most, if not all, of the effects of insulin. Mutations that diminish both the phosphorylation and the internalization of the insulin receptor block insulin action, as do antibodies which inhibit protein tyrosine kinase activity. Cells from patients with diabetic syndromes, characterized by non-responsiveness to insulin, exhibit reduced insulin dependent protein tyrosine kinase activity. Phosphorylation at Tyr 1162, Tyr 1163, and Tyr 1158 is required for the tyrosine kinase activity of the insulin receptor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PhosphoDetect™ Insulin Receptor (pTyr1162/1163)
Applications ELISA, Immunoblot, Immunoblot, Immunocytochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation In Dulbecco's PBS (without Mg2+ and Ca2+), 50% glycerol, 1mg/mL BSA, pH 7.3.
Host Species Rabbit
Immunogen a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr1162/1163 phosphorylation sites of human insulin receptor
Quantity 10 Tests
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽95kDaβ subunit of the insulin receptor protein phosphorylated at Tyr1162 and Tyr1163 in insulin receptor transfected cells. Cross-reacts with the insulin-like growth factor-1 receptor phosphorylated at Tyr1135 and Tyr1136.
Target Species Human
Content And Storage ≤ -70°C
Form Purified
Isotype IgG
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