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MilliporeSigma™ anti-PhosphoDetect JNK1/2 (pThr183/Tyr185), Polyclonal

Catalog No. PS1019100UL Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
PS1019100UL 100 μL Unconjugated
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Catalog No. PS1019100UL Supplier MilliporeSigma™ Supplier No. PS1019100UL
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Description

Rabbit Polyclonal Antibody

Specifically detects PhosphoDetect™ JNK1/2 (pThr183/Tyr185) Clone: in Human, Mouse, Rat samples, and it is validated for Immuno Blotting

c-Jun N-terminal Kinase (JNK) is a Stress Activated Protein Kinase/MAP Kinase (SAPK/MAPK) that exists as three isoforms, JNK1 (∽49kDa), JNK2 (∽55kDa), and JNK3 (∽54kDa). JNK is activated as a result of phosphorylation on Thr183 and Tyr185 by MEK4 and MEK7. JNK1 and JNK2 are expressed by numerous cells and tissues, while JNK3 is primarily expressed in neuronal cells. The JNK pathway, along with the p38 pathway, functions to modulate cell cycle, apoptotic, and transcriptional responses to stress.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PhosphoDetect™ JNK1/2 (pThr183/Tyr185)
Applications Immunoblot
Classification Polyclonal
Conjugate Unconjugated
Formulation In Dulbecco's PBS (without Mg2+ and Ca2+), 1mg/mL BSA, 50% glycerol, pH 7.2-7.4.
Host Species Rabbit
Immunogen a synthetic phosphopeptide corresponding to amino acids surrounding the Thr183 and Tyr185 phosphorylation sites of human JNK1 and JNK2
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽49kDa JNK1 and the ∽55kDa JNK2 phosphorylated at Thr183 and Tyr185 in uv-treated HEK293 cells.
Target Species Human, Mouse, Rat
Content And Storage −20°C
Form Purified
Isotype IgG
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For Research Use Only

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