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MilliporeSigma™ anti-PhosphoDetect Neurofilament H Clone: SMI-31,

Catalog No. NE1022100UL Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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NE1022100UL 100 μL Unconjugated
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Description

Mouse Monoclonal Antibody

Specifically detects Neurofilament H Clone: SMI-31 in Chicken, Xenopus samples, and it is validated for ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immuno Blotting

Neurofilaments are a type of intermediate filament that serve as major constituent of the cytoskeleton of axons. They are the most abundant fibrillar components of the axon and are composed of three intertwined protofibrils. The neurofilament triplet proteins (NF-L, 68/70kDa; NF-M, 160kDa; and NF-H, 200kDa) are found in both the central and peripheral nervous system and are usually neuron-specific. NF-H and NF-M both require the presence of NF-L protein to co-assemble. NF-H and NF-M become highly phosphorylated after newly formed neurofilaments enter the axon. Neurofilament staining is observed in neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas, and have also been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung are also known to express neurofilaments.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Neurofilament H
Applications ELISA, Immunoblot, Immunoblot, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone SMI-31
Conjugate Unconjugated
Formulation Undiluted ascites.
Host Species Mouse
Immunogen homogenized, hypothalami from Fischer 344 rat brain
Purification Method Unpurified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽180-200kDa phosphorylated neurofilament H protein in rat central nervous system (CNS) cytoskeletal preparations. Also weakly recognizes phosphorylated NF-M protein.
Target Species Chicken, Xenopus species
Content And Storage −20°C
Isotype IgG1
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For Research Use Only

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