MilliporeSigma™ anti-PhosphoDetect p38 MAP Kinase (pThr180, pTyr182), Polyclonal

Catalog No.	Quantity	Conjugate
50-611-910T	10 Tests	Unconjugated

Catalog No. 50-611-910T Supplier MilliporeSigma™ Supplier No. 50611910T

Description

Rabbit Polyclonal Antibody

Specifically detects PhosphoDetect™ p38 MAP Kinase (pThr¹⁸⁰, pTyr¹⁸²) Clone: in Canine, Human, Mouse, Rat samples, and it is validated for Immunocytochemistry

p38 MAP kinase (MAPK), also called RK and CSBP, is the mammalian homologue of yeast HOG kinase and participates in a cascade that controls cellular responses to cytokines and stress. Like the SAPK/JNK pathway, p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), UV light, and growth factors. Both MKK3 and SEK phosphorylate p38 on tyrosine and threonine resulting in p38 activation. Activated p38 MAPK has been shown to phosphorylate and activate MAPKAP kinase-2 and to phosphorylate the transcription factors ATF-2 and Max.

Specifications

• Antigen: PhosphoDetect™ p38 MAP Kinase (pThr¹⁸⁰, pTyr¹⁸²)
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: In Dulbecco's PBS (without Mg²⁺ and Ca²⁺), 1mg/mL BSA, 50% glycerol, pH 7.3.
• Host Species: Rabbit
• Immunogen: a synthetic phosphopeptide corresponding to amino acids surrounding the Thr¹⁸⁰ and Tyr¹⁸² phosphorylation sites of human p38 MAP Kinase
• Quantity: 10 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes p38α β and γ/ERK6 phosphorylated at Thr¹⁸⁰ and Tyr¹⁸² in uv-treated HEK293 cells and sorbitol-treated PC12 cells.
• Target Species: Canine, Human, Mouse, Rat
• Content And Storage: −20°C
• Form: Purified
• Isotype: IgG

For Research Use Only