MilliporeSigma anti-PhosphoDetect p53 (pSer15) (Ab-3), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC38650UL
Specifically detects PhosphoDetect p53 (pSer15) Clone: in Human, Mouse, Rat samples, and it is validated for Immunoprecipitationp53 tumor suppressor proteins play a key role in cellular defense against DNA damaging agents. p53 is phosphorylated at multiple sitesin vivo and by several different protein kinasesin vitro. DNA damage results in the phosphorylation of p53 at Ser15, leading to the reduced interactions of p53 with its negative regulator, the oncoprotein MDM2. p53 can be phosphorylated by ATM, by ATR, and by the DNA-dependent protein kinase (DNA-PK) at Ser15. This impairs the ability of MDM2 to bind p53 and promotes both the accumulation and functional activation of p53 in response to DNA damage.
|PhosphoDetect™ p53 (pSer15)|
|a synthetic phosphopeptide corresponding to amino acids surrounding the Ser15 phosphorylation site of human p53|
|Human, Murine, Rat|
|In 150mM NaCl, 10mM sodium HEPES, 100μg/mL BSA, 50% glycerol, pH 7.5.|
|Recognizes the ∽53kDa p53 protein phosphorylated at Ser15 in PC12 or HeLa cells treated with DNA damaging agents. Does not recognize unphosphorylated p53.|
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