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MilliporeSigma™ anti-PhosphoDetect p53 (pSer15) (Ab-3), Polyclonal

Catalog No. PC38650UL Shop All MilliporeSigma Products
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Quantity:
50 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
PC38650UL 50 μL Unconjugated
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Catalog No. PC38650UL Supplier MilliporeSigma™ Supplier No. PC38650UL
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Description

Rabbit Polyclonal Antibody

Specifically detects PhosphoDetect™ p53 (pSer15) Clone: in Human, Mouse, Rat samples, and it is validated for Immunoprecipitation

p53 tumor suppressor proteins play a key role in cellular defense against DNA damaging agents. p53 is phosphorylated at multiple sitesin vivo and by several different protein kinasesin vitro. DNA damage results in the phosphorylation of p53 at Ser15, leading to the reduced interactions of p53 with its negative regulator, the oncoprotein MDM2. p53 can be phosphorylated by ATM, by ATR, and by the DNA-dependent protein kinase (DNA-PK) at Ser15. This impairs the ability of MDM2 to bind p53 and promotes both the accumulation and functional activation of p53 in response to DNA damage.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PhosphoDetect™ p53 (pSer15)
Applications Immunoprecipitation
Classification Polyclonal
Conjugate Unconjugated
Formulation In 150mM NaCl, 10mM sodium HEPES, 100μg/mL BSA, 50% glycerol, pH 7.5.
Host Species Rabbit
Immunogen a synthetic phosphopeptide corresponding to amino acids surrounding the Ser15 phosphorylation site of human p53, conjugated to KLH
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽53kDa p53 protein phosphorylated at Ser15 in PC12 or HeLa cells treated with DNA damaging agents. Does not recognize unphosphorylated p53.
Target Species Human, Mouse, Rat
Content And Storage −20°C
Form Undiluted
Isotype IgG
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For Research Use Only

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