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MilliporeSigma™ anti-PhosphoDetect SAPK/JNK (pThr183, Tyr185), Polyclonal

Catalog No. 55930910T Shop All MilliporeSigma Products
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10 Tests
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Unconjugated
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55-930-910T 10 Tests Unconjugated
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Catalog No. 55-930-910T Supplier MilliporeSigma™ Supplier No. 55930910T
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Description

Rabbit Polyclonal Antibody

Specifically detects PhosphoDetect™ SAPK/JNK (pThr183, Tyr185) Clone: in C. elegans, Chicken, Drosophila, Human, Mouse, Rat samples, and it is validated for Immunohistochemistry

C-Jun-N-terminal kinase (JNK), also called stress-activated protein kinase (SAPK) is a member of the mitogen activated protein kinase (MAPK) family. JNK is activated in response to various extracellular stimuli, including pro-inflammatory cytokines. Phosphorylation of threonine and tyrosine in the Thr-Pro-Tyr domain is required for full activation. Mitogen activated protein kinase kinase (MKK4) preferentially phosphorylates tyrosine 185, and MKK7 causes preferential phosphorylation of threonine 183.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PhosphoDetect™ SAPK/JNK (pThr183, Tyr185)
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation In Dulbecco's PBS (without Mg2+ and Ca2+), 50% glycerol, 1mg/mL BSA, pH 7.3.
Host Species Rabbit
Immunogen a synthetic phosphopeptide corresponding to amino acids surrounding the Thr183 and Tyr185 phosphorylation sites of human SAPK/JNK
Quantity 10 Tests
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽49kDa SAPK1 protein and the ∽55kDa SAPK2 protein phosphorylated at Thr183 and Tyr185. Antibody Target Gene Symbol: MAPK8, MAPK9 Target Synonym: AI849689, C-JUN N-TERMINAL KINASE1, JNK, JNK1, JNK1 PROTEIN KINASE, JNK1A2, JNK21B1/2, p46JNK1, p46JNK1 ALPHA, PRKM8, Sapk gamma, SAPK P46, SAPK1, SAPK1/JNK, STRESS-ACTIVATED PROTEIN KINASE-LIKE KINASE, AI851083, Jnk p54, Jnk p55, JNK-55, JNK2, JNK2A, Jnk2a2, JNK2ALPHA, JNK2B, JNK2BETA, JUNKINASE, p54a, p54aSAPK, PRKM9, SAPK, SAPK ALPHA, SAPK ALPHA 1 Entrez Gene Name: mitogen-activated protein kinase 8
Target Species C. elegans, Chicken, Drosophila, Human, Mouse, Rat
Content And Storage ≤ -70°C
Form Purified
Isotype IgG
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