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MilliporeSigma™ anti-PhosphoDetect Shc/p66 (pSer36) Clone: 60000000000,

Catalog No. 5668071SET Shop All MilliporeSigma Products
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Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
56-680-71SET 1 Set Unconjugated
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Catalog No. 56-680-71SET Supplier MilliporeSigma™ Supplier No. 5668071SET
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Description

Mouse Monoclonal Antibody

Specifically detects Shc/p66 (pSer36) Clone: 60000000000 in Human, Mouse samples, and it is validated for ELISA, Immuno Blotting

Mammalian cells can express three alternatively spliced isoforms of the shc adaptor protein: Shc/p46, Shc/p52 and Shc/p66. Shc/p46 and Shc/p52 are found in every cell type, whereas Shc/p66 expression varies in different tissues. Shc proteins are phosphorylated by receptor tyrosine kinases and interact with phosphotyrosine residues on these receptors via the shc PTB and/or SH2 domains. The major tyrosine phosphorylation sites are tyrosines 239/240 as well as tyrosine 317. The Shc/p66 protein contains an additional N-terminal protein domain that is phosphorylated at serine 36. It is suggested that only the serine-phosphorylated Shc/p66 can interact with GRB2. Moreover, expression of Shc/p66 accelerates the inactivation of MAP kinases after EGF stimulation, whereas Shc/p46 and Shc/p52 enhance MAP kinase activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Shc/p66 (pSer36)
Applications ELISA, Immunoblot, Immunoblot
Classification Monoclonal
Clone 60000000000
Conjugate Unconjugated
Formulation 100μg antibody lyophilized from 2X PBS, PEG, sucrose and 125μL control protein lyophilized from 2X PBS.
Host Species Mouse
Immunogen a synthetic phosphopeptide corresponding to amino acids surrounding the Ser36 phosphorylation site of human Shc/p66
Quantity 1 Set
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽66kDa form of Shc phosphorylated at Ser36. Does not cross-react with the non-phosphorylated form of Shc/p66 or with unrelated phosphorylation sites.
Target Species Human, Mouse
Content And Storage −20°C
Form Purified
Isotype IgG1
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