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MilliporeSigma™ anti-PhosphoDetect Syk (pTyr525/526), Polyclonal

Catalog No. PK101050UL Shop All MilliporeSigma Products
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Quantity:
50 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
PK101050UL 50 μL Unconjugated
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Catalog No. PK101050UL Supplier MilliporeSigma™ Supplier No. PK101050UL
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Description

Rabbit Polyclonal Antibody

Specifically detects PhosphoDetect™ Syk (pTyr525/526) Clone: in Human, Mouse samples, and it is validated for ELISA, Immuno Blotting

Syk is a protein tyrosine kinase that is widely expressed and plays a key role in hematopoietic cell signaling. Syk is reported to interact with immunoreceptor tyrosine-based activation motifs (ITAMs) found in the cytoplasmic domains of immune receptors. This interaction serves to couple activated immune receptors to downstream signaling events that mediate diverse cellular responses, such as proliferation, differentiation, and phagocytosis. Syk is also reported to act as a potential tumor suppressor in human breast carcinomas. Phosphorylation of Tyr525/526, located in the activation loop of human Syk, is required for Syk activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PhosphoDetect™ Syk (pTyr525/526)
Applications ELISA, Immunoblot, Immunoblot
Classification Polyclonal
Conjugate Unconjugated
Formulation In 150mM NaCl, 10mM sodium HEPES, 100μg/mL BSA, 50% glycerol, pH 7.5.
Host Species Rabbit
Immunogen a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr525/526 phosphorylation sites of human Syk
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽72kDa Syk protein phosphorylated at Tyr525/526 in human Syk or Tyr519/520 in mouse Syk in 293T cells expressing wild-type Syk and CD8.
Target Species Human, Mouse
Content And Storage −20°C
Form Purified
Isotype IgG
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For Research Use Only

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