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MilliporeSigma™ anti-PhosphoDetect Tau (pSer396), Polyclonal

Catalog No. 57781510T Shop All MilliporeSigma Products
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10 Tests
Conjugate:
Unconjugated
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57-781-510T 10 Tests Unconjugated
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Catalog No. 57-781-510T Supplier MilliporeSigma™ Supplier No. 57781510T
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Description

Rabbit Polyclonal Antibody

Specifically detects PhosphoDetect™ Tau (pSer396) Clone: in Human samples, and it is validated for Immuno Blotting

Tau is the microtubule-associated protein predominantly found in neurons. It promotes assembly of tubulin into microtubules. Tau is also a phosphoprotein and its biological activity is regulated by the degree of phosphorylation. In the brain of Alzheimer's patients, tau is hyperphosphorylated and exists as both a cytosolic protein and as polymerized paired helical filaments (PHF). The PHF form the building blocks for neurofibrillary tangles that are the hallmark of AD brains. Hyperphosphorylated tau in AD inhibits the assembly of microtubules and causes disassembly of preassembled microtubules. Ultimately, hyperphosphorylated tau leads to the degeneration of the neurons and forms the pathogenic mechanism for Alzheimer's disease. In addition to AD brains, neurofibrillary tangles have also been observed in brains of patients with Niemann-Pick type C (NPC) disease. NPC is associated with the accumulation of cholesterol in several tissues and with progressive neurodegeneration. It has recently been shown that brains of NPC patients also accumulate neurofibrillary tangles without amyloid deposits. As in AD brains, the PHF of NPC brains are the result of hyperphosphorylation of tau. In tau, serine 396 is one of the four most prominent phosphorylation sites used by GSK-3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PhosphoDetect™ Tau (pSer396)
Applications Immunoblot
Classification Polyclonal
Conjugate Unconjugated
Formulation In Dulbecco's PBS (without Mg2+ and Ca2+), 1mg/mL BSA, 50% glycerol, pH 7.2-7.4.
Host Species Rabbit
Immunogen a synthetic phosphopeptide corresponding to amino acids surrounding the Ser396 phosphorylation site of human Tau
Quantity 10 Tests
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽45-68kDa Tau protein phosphorylated at Ser396.
Target Species Human
Content And Storage −20°C
Form Purified
Isotype IgG
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