Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

PI3-Kinase C2β Mouse anti-Human, Unlabeled, Clone: 22, BD

Mouse Monoclonal Antibody

$287.50

Specifications

Antigen PI3-Kinase C2β
Clone 22
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
View More Specs

Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611342
View Documents
BD Biosciences
611342
50 μg
Each of 1 for $287.50
Only null left
Add to Cart
 
Description

Description

Phosphatidylinositol (PtdIns) (3) kinase phosphorylates the D-3 position of the inositolring of PtdIns, producing PtdIns(3)P, PtdIns(3,4)P2, and PtdIns(3,4,5)P3. PI3-kinase is a heterodimer of an 85kDa regulatory subunit (p85) and a 110kDa catalytic subunit (p110). However, it is only one member of a larger family of proteins with similarity to the p110 subunit. These different PI3-kinase isoforms have been divided into three classes. Class I consists of p110α and p110-» which bind the p85 subunit and associate with receptor tyrosine kinases. Class II includes 68D and cpk from Drosophila, p170 and cpk-m from mouse, and C2α, C2-» (HsC2), and C2γ from human. These proteins phosphorylate PtdIns and PtdIns(4)P, but not PtdIns(4,5)P2, and each contain a C-terminal C2 domain that may negatively regulate the catalytic domain. Class III members only phosphorylate PtdIns to PtdIns(3)P and include the S. cerevisiae Vps34p and its human homologs. In humans, the class II PI3-kinases C2α and C2-» have similar catalytic, PI kinase, and C2 domains. However they differ in their N-terminal regions. In addition, C2β has no cation specificity, while C2α prefers Mg2+-ATP for optimal phosphorylation.

Host Species: Mouse
Clone: 22
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human PI3-Kinase C2β aa. 16-209
Formula Weight [Chemical]: 165kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

PI3-Kinase C2β
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
22
Western Blot
Unconjugated
RUO
Human
Human PI3-Kinase C2β aa. 16-209
Primary
Store undiluted at -20°C.
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only.

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.