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PI3-Kinase C2β Mouse anti-Human, Unlabeled, Clone: 22, BD

Mouse Monoclonal Antibody

$232.00 - $431.00

Specifications

Antigen PI3-Kinase C2β
Isotype IgG1
Immunogen Human PI3-Kinase C2β aa. 16-209
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611342
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BD Biosciences
611342
50μg
Each for $232.00
Add to cart
 
BDB611343
View Documents
BD Biosciences
611343
150μg
Each for $431.00
Add to cart
 
Description

Description

Phosphatidylinositol (PtdIns) (3) kinase phosphorylates the D-3 position of the inositolring of PtdIns, producing PtdIns(3)P, PtdIns(3,4)P2, and PtdIns(3,4,5)P3. PI3-kinase is a heterodimer of an 85kDa regulatory subunit (p85) and a 110kDa catalytic subunit (p110). However, it is only one member of a larger family of proteins with similarity to the p110 subunit. These different PI3-kinase isoforms have been divided into three classes. Class I consists of p110α and p110-» which bind the p85 subunit and associate with receptor tyrosine kinases. Class II includes 68D and cpk from Drosophila, p170 and cpk-m from mouse, and C2α, C2-» (HsC2), and C2γ from human. These proteins phosphorylate PtdIns and PtdIns(4)P, but not PtdIns(4,5)P2, and each contain a C-terminal C2 domain that may negatively regulate the catalytic domain. Class III members only phosphorylate PtdIns to PtdIns(3)P and include the S. cerevisiae Vps34p and its human homologs. In humans, the class II PI3-kinases C2α and C2-» have similar catalytic, PI kinase, and C2 domains. However they differ in their N-terminal regions. In addition, C2β has no cation specificity, while C2α prefers Mg2+-ATP for optimal phosphorylation.

Host Species: Mouse
Clone: 22
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human PI3-Kinase C2β aa. 16-209
Formula Weight [Chemical]: 165kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

PI3-Kinase C2β
Human PI3-Kinase C2β aa. 16-209
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
22
250μg/mL
SDS
Product Certifications

For Research Use Only.

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