Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

PI3-Kinase p110α Mouse, Unlabeled, Clone: 19, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611399

 View more versions of this product

Catalog No. BDB611399


Add to cart

Description

Description

Phosphatidylinositol 3 (PI3) -kinase participates in insulin-stimulated glucose uptake, PDGF-induced membrane ruffling, and G-protein receptor signaling. It exists as a heterodimer of 85kDa (p85) and 110kDa (p110) subunits. The p85 subunit associates with and serves as a substrate for activated growth factor receptor tyrosine kinases. p85 regulates the p110 catalytic subunit by acting as the link between PI3-kinase and the ligand-activated receptor. Four isoforms of p110 have been identified (α, β, γ, and δ). The p110α isoform contains an N-terminal region involved in p85 binding and a C-terminal kinase domain. p85/p110α-type PI kinase phosphorylates the D-3 and D-4
position of the inositol ring of PI, thereby producing PtdIns(3)P, PtdIns(3,4)P[2], PtdIns(3,4,5)P[3], PtdIns(4)P, and PtdIns(4,5) P[2]. During induction of chemotaxis by the chemokine SDF-1α, PI3-kinase regulates adhesion and ERM protein redistribution in the lymphocyte plasma membrane. In addition, PI3-kinases activate other signaling molecules, such as p70 S6 kinase and Akt/protein kinase B. Thus, p85/p110α-type PI kinase is a ubiquitously expressed kinase that is involved in a variety of cell signaling cascades.

Host Species: Mouse
Clone: 19
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human PI3-Kinase p110α aa. 101-300
Formula Weight [Chemical]: 110kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

PI3-Kinase p110α
19
Unconjugated
Affinity Purified
Human PI3-Kinase p110α aa. 101-300
150μg
Cell Biology
Primary
Human, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only.