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PI3-Kinase p110α Mouse, Unlabeled, Clone: 19, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611399

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Catalog No. BDB611399

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Phosphatidylinositol 3 (PI3) -kinase participates in insulin-stimulated glucose uptake, PDGF-induced membrane ruffling, and G-protein receptor signaling. It exists as a heterodimer of 85kDa (p85) and 110kDa (p110) subunits. The p85 subunit associates with and serves as a substrate for activated growth factor receptor tyrosine kinases. p85 regulates the p110 catalytic subunit by acting as the link between PI3-kinase and the ligand-activated receptor. Four isoforms of p110 have been identified (α, β, γ, and δ). The p110α isoform contains an N-terminal region involved in p85 binding and a C-terminal kinase domain. p85/p110α-type PI kinase phosphorylates the D-3 and D-4
position of the inositol ring of PI, thereby producing PtdIns(3)P, PtdIns(3,4)P[2], PtdIns(3,4,5)P[3], PtdIns(4)P, and PtdIns(4,5) P[2]. During induction of chemotaxis by the chemokine SDF-1α, PI3-kinase regulates adhesion and ERM protein redistribution in the lymphocyte plasma membrane. In addition, PI3-kinases activate other signaling molecules, such as p70 S6 kinase and Akt/protein kinase B. Thus, p85/p110α-type PI kinase is a ubiquitously expressed kinase that is involved in a variety of cell signaling cascades.

Host Species: Mouse
Clone: 19
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human PI3-Kinase p110α aa. 101-300
Formula Weight [Chemical]: 110kDa

Immunofluorescence, Western Blotting



PI3-Kinase p110α
Affinity Purified
Human PI3-Kinase p110α aa. 101-300
Cell Biology
Human, Rat
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
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