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PI3 Kinase p110δ Mouse, Unlabeled, Clone: 29, BD

Catalog No. BDB611014 Shop All BD Biosciences Products
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BDB611014 50 μg
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Catalog No. BDB611014 Supplier BD Biosciences Supplier No. 611014

Description

Mouse Monoclonal Antibody

Phosphoinositide 3 Kinase (PI3 Kinase) phosphorylates the D-3 position of the inositol ring of phosphatidylinositol, producing PtdIns(3)P, PtdIns(3,4)P2, and PtdIns (3,4,5)P3. PI3-kinase is a heterodimer of an 85kDa regulatory subunit (p85) containing two SH2 domains and an SH3 domain, and a 110kDa catalytic subunit (p110). Four isoforms of p110 have been identified (α , β , γ, and δ). The p110α, β isoforms are distributed ubiquitously. The p110δ isoform is found exclusively in lymphocytes and lymphoid tissues. Lymphocytes also contains p110α and both isoforms interact with p85 and are recruited to activated signaling complexes. However, several biochemical and structural differences distinguish p110δ. Unlike p110α, p110δ autophosphorylates and does not phosphorylate p85. In addition, p110δ contains a Pro-rich region, which endows it with the potential for interaction with SH3 domain-containing proteins, and a bZIP-like domain, which is a common transcription factor domain that has also been identified in certain protein kinases. With the established role of PI3-Ks in cytoskeletal rearrangements, it is thought that p110δ contributes specifically to the regulation of lymphocytes extravasation into tissues. There is a high degree of homology in the immunogen region with the P110β form (77%), and it is likely that our antibody will detect both the beta and delta forms.

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen PI3 Kinase p110δ
Applications Western Blot
Classification Monoclonal
Clone 29
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse PI3 Kinase p110δ aa. 73-90
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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