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CALM Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520871

Catalog No. PIPA520871


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Description

Description

A suggested positive control is EL4 cell lysate. PA5-20871 can be used with blocking peptide PEP-0985.

PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer ft.s disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).
Specifications

Specifications

CALM
Polyclonal
Unconjugated
PICALM
Liquid
PICALM
A 15 amino acid peptide from near the amino terminus of human PICALM.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q13492, Q7M6Y3, O55012
CALM, CLTH, LAP; clathrin assembly lymphoid myeloid leukemia protein; phosphatidylinositol-binding clathrin assembly protein
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
233489, 8301, 89816
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