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PIN Mouse, Unlabeled, Clone: 4, BD

Catalog No. BDB610726 Shop All BD Biosciences Products
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BDB610726 50 μg
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Catalog No. BDB610726 Supplier BD Biosciences Supplier No. 610726

Description

Mouse Monoclonal Antibody

PIN (protein inhibitor of nNOS) is a small protein of 89 amino acids initially described as a light chain subunit of dynein and as an inhibitor of the neuronal nitric oxide synthase isoform (nNOS). In vitro, PIN has been reported to bind to a unique nNOS domain encompassing amino acids 163-245. PIN inhibits nNOS activity and blocks the formation of the active nNOS dimer. Although ubiquitously expressed, PIN levels are reportedly highest in brain and testis. Immunolocalization studies in Drosophila melanogaster detected a cytoplasmic distribution of PIN. Partial-loss-of-function of PIN resulted in morphologic and developmental changes in the bristles, wings, and female sterility of D. melanogaster. Deletion of PIN resulted in lethality with the characteristic morphology of apoptotic cells.

Immunofluorescence, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen PIN
Applications Immunofluorescence, Western Blot
Classification Monoclonal
Clone 4
Concentration 250μg/mL
Conjugate Unconjugated
Description Protein Inhibitor of nNOS
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Rat PIN aa. 1-89
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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