PINK1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523072
Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson’s disease are triggered. PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects.
|A synthetic peptide made to an internal region of the human PINK1 protein (within residues 350-500).|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)|
|PBS with 0.05% sodium azide|
|BRPK, PARK6, PTEN-induced putative kinase protein 1, protein kinase BRPK, serine/threonine-protein kinase PINK1, mitochondrial|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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