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PINK1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523072

Catalog No. PIPA523072


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Description

Description

Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson’s disease are triggered. PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects.
Specifications

Specifications

PINK1
Polyclonal
Unconjugated
PINK1
Liquid
PINK1
A synthetic peptide made to an internal region of the human PINK1 protein (within residues 350-500).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
1.2 mg/mL
PBS with 0.05% sodium azide
Q9BXM7, Q99MQ3
BRPK, PARK6, PTEN-induced putative kinase protein 1, protein kinase BRPK, serine/threonine-protein kinase PINK1, mitochondrial
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
65018, 68943
Documents
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