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PIR-A/B Rat anti-Mouse, Unlabeled, Clone: 6C1, BD

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BDB550348 0.1 mg
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Catalog No. BDB550348 Supplier BD Biosciences Supplier No. 550348
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Description

Rat Monoclonal Antibody

The 6C1 antibody reacts with common epitopes of PIR-A and PIR-B (Paired Immunoglobulin-liked Receptors) in all mouse strains tested (A/J, BALB/cJ, C3H, C57BL/6, DBA/1, DBA/2, NZB, and SJL). PIR-A and PIR-B are type-I transmembrane glycoproteins containing six Ig-like domains. There are multiple PIR-A proteins which are activating receptors by virtue of their intracellular association with the ITAM (Immunoreceptor Tyrosine-based Activation Motif)- containing Fc receptor γ chain (FcRγ) in mast cells and macrophages. FcRγ expression is required for PIR-A cell-surface expression on dendritic cells, B cells, and myeloid lineages. In contrast, PIR-B is an inhibitory receptor which contains various ITIMs (Immunoreceptor Tyrosine-based Inhibitory Motifs) in its cytoplasmic domain. These receptors are expressed on B cells, granulocytes, mast cells, dendritic cells, and monocytes/macrophages, but not on thymocytes, T lymphocytes, erythroid lineage cells, or NK cells. The level of cell-surface expression of these receptors increases as a function of B-cell activation and myeloid- and B-lineage differentiation. The 6C1 antibody immunoprecipitates molecules of 85- and 125kDa, which correspond to PIRA and PIR-B, respectively.

Host Species: Rat
Clone: 6C1
Isotype: IgG1 κ
Species Reactivity: Mouse
Immunogen: Recombinant mouse PIR-A1 extracellular domain peptide and the mouse myeloid cell line, WEH13

Flow Cytometry, Immunoprecipitation

TRUSTED_SUSTAINABILITY

Specifications

Antigen PIR-A/B
Applications Flow Cytometry
Classification Monoclonal
Clone 6C1
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Recombinant mouse PIR-A1 extracellular domain peptide and the mouse myeloid cell line, WEH13
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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For Research Use Only.

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