Phospho-PKA alpha/beta (Thr197), Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA128490

Catalog No. PIPA128490

Description

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

PA1-28490 detects PKA alpha + beta from mouse, human samples.PA1-28490 has been successfully used in Western blot applications.The PA1-28490 immunogen is: Synthetic phosphopeptide derived from a region of human PKA that contains threonine 197.

Specifications

• Antigen: Phospho-PKA alpha + beta pThr197
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Accession No.: P00517, P05131, P17612, P22694, P05132, P68181, P05383, P36887, P27791, P68182
• Gene Symbols: PRKACA, PRKACB
• Immunogen: Synthetic phosphopeptide derived from a region of human PKA that contains threonine 197.
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Human, Mouse, Pig, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 0.35mg/mL
• Gene: PRKACA
• Gene Alias: PRKC Pan, Protein kinase C alpha type, PKC-A, PKC-alpha, PRKCA, PKCA, PRKACA, PKCB, PRKCB1, Protein kinase C beta type, PKC-B, PKC-beta
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5566, 5567
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Purified