Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

PKA RIIβ Mouse, Unlabeled, Clone: 45, BD

Mouse Monoclonal Antibody

$232.00 - $458.00

Specifications

Antigen PKA RIIβ
Isotype IgG1
Immunogen Human PKA RIIβ, aa 1-418
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610625
View Documents
BD Biosciences
610625
50μg
Each for $232.00
Add to cart
 
BDB610626
View Documents
BD Biosciences
610626
150μg
Each for $458.00
Add to cart
 
Description

Description

cAMP-dependent Protein Kinase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R). Four regulatory subunits have been identified: RIα, RIβ, RIIα, and RIIβ.These subunits define type I and II cAMP-dependent protein kinases. Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active. Type I and type II holoenzymes have three potential C subunits (Cα, Cβ, or Cγ). Type II PKA can be distinguished by autophosphorylation of the R-subunits, while type I PKA binds Mg/ATP with high affinity. Most cells express both type I and type II PKAs. Although the Rα isoforms are ubiquitously expressed, the Rβ isoforms are predominant in nervous and adipose tissues. There are indications that the deletion of the gene for PKA RIIβ results in lack of long-term potentiation in a select group of hippocampal cells, suggesting an important role for this protein in the neurosciences.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

PKA RIIβ
Human PKA RIIβ, aa 1-418
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
45
250μg/mL
SDS
Product Certifications

For Research Use Only.

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit