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PKA RIIα (pS99) Mouse anti-Human, Alexa Fluor 647, Clone: I65-856.286, BD

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Description

Mouse Monoclonal Antibody

cAMP-dependent Protein Kinase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R). Four regulatory subunits have been identified: RIα, RIβ, RIIα, and RIIβ. These subunits define type I and II PKAs. Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active. Type I and II holoenzymes have three potential C subunits (Cα, Cβ, or Cγ). Type II PKA can be distinguished by autophosphorylation of the R subunits, while type I PKA binds Mg/ATP with high affinity. The cAMP-dependent autophosphorylation of the human RIIα subunit occurs at Serine 99 (S99) (Entrez Protein Accession No.CAA33094). Most cells express both type I and type II PKAs. Although the Rα isoforms are ubiquitously expressed, the Rβ isoforms are predominantly found in nervous and adipose tissues. In addition to their enzyme regulatory activity, the RIIα and RIIβ subunits determine the subcellular location of the holoenzymes via their interactions with specific intracellular anchoring proteins. The I65-856.286 antibody recognizes human PKA RIIα phosphorylated at S99.

Host Species: Mouse
Clone: I65-856.286
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Phosphorylated Human PKA RIIα Peptide

Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen PKA RIIα (pS99)
Applications Flow Cytometry
Classification Monoclonal
Clone I65-856.286
Conjugate Alexa Fluor 647
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human PKA RIIα Peptide
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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